Publications – supported by the OR Foundation

Innovation is linked to research, and publication of research results is a fundamental element of scientific activities. The OR Foundation encourages the publication of projects and studies in peer-reviewed journals. To maintain an accurate and updated reference of related publications, authors of OR Foundation supported Research grant projects are invited to send reprints of their publications.

Find out more about the Purpose and Mission of the Oral Reconstruction Foundation.

 

A non-interventional multicenter study to document the implants success and survival rates in daily dental practices of the CONELOG screw-line implant.

This multicenter prospective non-interventional study evaluated the success and survival of the CONELOG implants inserted according to the standard protocol with one- or two-step surgery in daily practice three years after loading. Changes of soft tissue and bone level over time, esthetical outcome, and patient satisfaction were assessed.

Cacaci C, Ackermann KL, Barth T, Kistler S, Stiller M, Schlee M.
Clin Oral Investig 2018 Oct 15. Doi: 10.1007/s00784-018-2646-0. [Epub ahead of print] (Grant CF2010-NISCAM01F)


Implant success and survival rates in daily dental practice: 5-year results of a non-interventional study using CAMLOG SCREW-LINE implants with or without platform-switching abutments.

The performance of dental implants in controlled clinical studies is often investigated in homogenous populations. Observational studies are necessary to evaluate the outcome of implant restorations placed in real-life situations, according to standard practice, and to assess the needs of the patients. The aim of this non-interventional study was to reveal the survival, success, and general performance of CAMLOG SCREW-LINE implants and their restorations in daily dental practice.

Beschnidt SM, Cacaci C, Dedeoglu K, Hildebrand D, Hulla H, Iglhaut G, Krennmair G, Schlee M, Sipos P, Stricker A, Ackermann KL.
Int J implant Dent 2018;4:33 doi.org/10.1186/s40729-018-0145-3 (Grant CF2009-3.006F)


Clinical evaluation of non-surgical cleaning modalities on titanium dental implants during maintenance care: a 1-year follow-up on prosthodontic superstructures.

To investigate tissue health around implants with newly attached superstructures over 12 months of preventive maintenance appointments and instrumentation when necessary.

Schmidt KE, Auschill TM, Sculean A, Arweiler NB.
Clin Oral Investig 2018 Sep 19. doi: 10.1007/s00784-018-2640-6. [Epub ahead of print] (Grant CF41203)


Retrievability of implant-supported zirconia restorations cemented on zirconia abutments.

The purpose of this in vitro study was to investigate the influence of different cements and marginal discrepancy on the retrievability of implant-supported zirconia crowns. Furthermore, the influence of thermocycling on retrievability was evaluated.

Lennartz A, Dohmen A, Bishti S, Fischer H, Wolfart S.
J Prosthet Dent 2018 May 25. pii: S0022-3913(18)30086-6. doi: 10.1016/j.prosdent.2018.01.011. [Epub ahead of print] (Grant CF21006)


Alveolar ridge preservation with a collagen material: a randomized controlled trial.

Resorption of the alveolar bone is an unavoidable consequence of tooth extraction when appropriate alveolar ridge preservation (ARP) measures are not taken. The objective of this trial was to test the hypothesis that dimensional changes in the alveolar bone after tooth extraction would be reduced by inserting an equine collagen membrane and a collagen cone to fill and seal the alveolus (as ARP), in comparison to extraction with untreated alveoli.

Schnutenhaus S, Doering I, Dreyhaupt J, Rudolph H, Luthardt RG.
J Periodontal Implant Sci 2018 Aug;48(4):236-250. doi.org/10.5051/jpis.2018.48.4.236 [Epub ahead of print] (Grant CF41305)


Reproducibility of CBCT image analysis: a clinical study on intrapersonal and interpersonal errors in bone structure determination.

For correct implant planning based on cone-beam computed tomography (CBCT), the bone contour must be accurately determined. Identification of the contour is difficult in bones with incomplete mineralization. In this clinical study, we investigated the intrapersonal and interpersonal reproducibilities of manual bone contour determination on CBCT images using a semi-automated computerized process.

Schnutenhaus S, Graf M, Doering I, Luthardt RG, Rudolph H
Oral Radiol (2018) doi.org/10.1007/s11282-018-0340-1 [Epub ahead of print] (Grant CF41305)


Accuracy of the match between cone beam computed tomography and model scan data in template-guided implant planning: A prospective controlled clinical study.

The objective of this prospective controlled clinical study was to determine and compare the accuracy of the match with and without an additional X-ray template.

Schnutenhaus S, Gröller S, Luthardt RG, Rudolph H
Clin Implant Dent Relat Res 2018 Apr 25. doi: 10.1111/cid.12614. [Epub ahead of print] (Grant CF41305)


Onset, progression and resolution of experimental peri-implant mucositis at different abutment surfaces: A randomized controlled two-center study.

To assess the onset, progression and resolution of experimentally induced peri-implant mucositis lesions at abutments with different microstructures in humans.

Schwarz F, Becker J, Civale S, Hazar D, Iglhaut T, Iglhaut G
J Clin Periodontol 2018;1-13 DOI: 10.1111/jcpe.12868 (Grant CF41502)


Clinical and laboratory evaluation of the effects of different treatment modalities on titanium healing caps: a randomized, controlled clinical trial.

The objective of this study is to evaluate the effects of treatment modalities on titanium surface characteristics and surrounding tissues.

Schmidt KE, Auschill TM, Heumann C, Frankenberger R, Eick S, Sculean A, Arweiler NB
Clin Oral Investig 2017 Dec 27. doi: 10.1007/s00784-017-2287-8 [Epub ahead of print] (Grant CF41203)


Effects of modified abutment characteristics on peri-implant soft tissue health: A systematic review and meta-analysis.

The purpose of this systematic review was to evaluate the impact of the abutment characteristics on peri-implant tissue health and to identify the most suitable material and surface characteristics.

Sanz-Martín I, Sanz-Sánchez I, Carrillo de Albornoz A, Figuero E, Sanz M
Clin Oral Implants Res 2017;1-2. Doi: 10.1111/crl.13097 [Epub ahead of print]


Immediate definitive individualized abutments reduce peri-implant bone loss: a randomized controlled split-mouth study on 16 patients.

This paper aims to observe peri-implant time-related vertical bone level and soft tissue changes with immediate, non-detached glass-ceramic (lithium-disilicate) individualized abutments and dis-/reconnections.

Cömlekoglu E, Nizam N, Cömlekoglu MD
Clin Oral Invest 2017 DOI 10.1007/s00784-017-2136-9 (ahead of print) (Grant CF41104)


Mechanical performance of cement- and screw-retained all-ceramic single crowns on dental implants.

This in-vitro study was performed to compare the contact wear, fracture strength and failure mode of implant-supported all-ceramic single crowns manufactured with various fabrication and fixation concepts.

Obermeier M, Ristow O, Erdelt K, Beuer F
Clin Oral Invest 2017 DOI 10.1007/s0078-017-2178-z (Grant CF51202)


Photofunctionalization and non-thermal plasma activation of titanium surfaces.

The aim of this study was to compare UV light and non-thermal plasma (NTP) treatment regarding the improvement of physical material characteristics and cell reaction on titanium surfaces in vitro after short-term functionalization.

Henningsen A, Smeets R, Hartjen P, Heinrich O, Heuberger R, Heiland M, Precht C, Cacaci C
Clin Oral Invest 2017 DOI 10.1007/s00784-017-2186-z (Grant CF11501)


Neurophysiological changes associated with implant-associated augmentation procedures in the lower jaw.

Neurophysiological changes after oral and maxillofacial surgery remain one of the topics of current research. This study evaluated if implant placement associated with augmentation procedures increases the possibility of sensory disturbances or result in impaired quality of life during the healing period.

Hartmann A, Welte-Jzyk C, Seiler M, Daubländer M
Clin Implant Dent Relat Res 2017;19:725-32 (Grant CF41603)


Alveolar Ridge Preservation as a Way to Reduce the Need for Bone Augmentation: Implementation of a New, Non-invasive Method of Measuring Bone Preservation: Study Protocol of a Randomized Controlled Clinical Trial and Feasibility Testing Results.

The efficacy of alveolar ridge preservation (ARP) in preserving the bone after tooth extractions and before rehabilitation with an implant-supported restoration is examined. A new, non-invasive measurement method to determine the extent of bone preservation is presented. This measurement method is based on a 3D comparison of the condition immediately after extraction with the data of a cone-beam computed tomography (CBCT) eight weeks after extraction.

Schnutenhaus S, Doering I, Dreyhaupt J, Rudolph H, Luthardt RG
Int J Clin Res Trials 2017; 2:116 (Grant CF41305)


The prevalence of peri-implant diseases for two-piece implants with an internal tube-in-tube connection: a cross-sectional analysis of 512 implants.

To assess the prevalence of peri-implant health or disease for a two-piece implant system with a tube-in-tube internal connection on the short-, medium- and long term.

Schwarz F, Becker K, Sahm N, Horstkemper T, Rousi K, Becker J
Clin Oral Implants Res 2017 Jan;28(1):24-28 (Grant CF41204)


The effect of one-time abutment placement on interproximal bone levels and peri-implant soft tissues: a prospective randomized clinical trial.

To compare the effect of placing the definitive abutment at the time of implant placement versus at a later stage, on the soft and hard tissue changes around dental implants.

Molina A, Sanz-Sánchez I, Martín C, Blanco J, Sanz M
Clin Oral Implants Res 2017 Apr;28(4):443-52 (Grant CF2010)


Volumetric analysis of bone substitute material performance within the human sinus cavity of former head and neck cancer patients: A prospective, randomized clinical trial.

The aim of the present study was to assess the volume and density of a xenogeneic (Bio-Oss®, BO) and a synthetic (NanoBone®, NB) bone substitute material in split-mouth sinus augmentations in former tumor patients to complete histological and histomorphometrical assessment.

Lorenz J, Eichler K, Barbeck M, Lerner H, Stübinger S, Seipel C, Vogl J, Kovács AF, Ghanaati S, Sader RA
Ann Maxillofac Surg 2016 Jul-Dec;6(2):175-181 (Grant CF2006)


Fracture resistance of different implant abutments supporting all-ceramic single crowns after aging.

To test the mechanical properties of three different restorative materials for implant abutments supporting all-ceramic single crowns.

Stimmelmayr M, Heiss P, Erdelt K, Schweiger J, Beuer F
Int J Computerized Dent 2017;20(1):53-64 (Grant CF51201)


Adhesion of living cells to abutment materials, dentin, and adhesive luting cement with different surface qualities.

We tested the adhesion properties of living gingival fibroblasts on three different implant abutment materials, adhesive resin used to bond bi-partite abutments, and human dentin.

Mehl C, Kern M, Schütte AM, Kadem LF, Selhuber-Unkel C
Dent Mater 2016;32(12):1524-35 (Grant CF21405)


Loading protocols and implant supported restorations proposed for the rehabilitation of partially and fully edentulous jaws. Camlog Foundation Consensus Report.

The aim of this consensus meeting was to assess whether immediate loading protocols achieve comparable clinical outcomes when compared to conventional loading protocols depending on the type of prosthetic restoration. In addition post-loading implant loss for implant supported prostheses in edentulous jaws was analyzed regarding a potential impact of implant location (maxilla vs. mandible), implant number per patient, type of prosthesis (removable vs. fixed), and type of attachment system (screw-retained, ball vs. bar vs. telescopic crown).

Schwarz F, Sanz-Martín I, Kern JS, Taylor T, Schaer A, Wolfart S, Sanz M.
Clin Oral Implants Res 2016;27(8):988-92


Three-dimensional assessment of crestal bone levels at titanium implants with different abutment microstructures and insertion depths using micro-computed tomography.

To (i) assess the impact of insertion depth and abutment microstructure on the three-dimensional crestal bone-level changes at endosseous titanium implant using μCT and computerized image processing and (ii) to correlate the findings with previously reported histology.

Becker K, Klitzsch I, Strauber M, Schwarz F
Clin Oral Impl Res 2017;28:671-6 (Grant CF31301)


Sinus floor elevation and augmentation using synthetic nanocrystalline and nanoporous hydroxyapatitie bone substitute materials: preliminary histologic results.

To compare the tissue composition of augmented sites after using two different synthetic bone substitute materials, nanocrystalline and nanoporous hydroxyapatite (HA), for sinus floor elevation and augmentation.

Belouka S-M, Strietzel FP
Int J Maxillofac Implants 2016;31:1281-91 (Grant CF40804)


Neurophysiological changes associated with implant placement.

The objective of the study was to evaluate the feasibility of a standardized Quantitative Sensory Testing (QST) protocol extra- and intraoral in patients to detect and quantify sensory disturbances of the inferior alveolar nerve due to the proximity of implantation procedures to the inferior alveolar nerve canal.

Hartmann A, Welte-Jzyk C, Seiler M, Daubländer M
Clin Oral Impl Res 2017;28:576-81 (Grant CF41208)


A randomized controlled clinical trial comparing small buccal dehiscence defects around dental implants treated with guided bone regeneration or left for spontaneous healing.

The aim of the present randomized controlled clinical study was to test whether small bony dehiscence defects (≤5 mm) left to heal spontaneously result in the same clinical and radiological outcome as defects treated with guided bone regeneration (GBR).

Jung RE, Herzog M, Wolleb K, Ramel CF, Thoma DS, Hämmerle CHF
Clin Oral Impl Res 2017;28(3):348-54 (Grant CF40806)


Influence of four different abutment materials and the adhesive joint of two-piece abutments on cervical implant bone and soft tissue.

The main aim of this study was to evaluate the influence of four different abutment materials and the adhesive joint of two-piece abutments on the cervical implant bone and soft tissue.

Mehl C, Gassling V, Schultz-Langerhans S, Açil Y, Bähr T, Wilfgang J, Kern M
Int J Oral Maxillofac Implants 2016;31:1264-72 (Grant CF31401)


Effect of platform switching on crestal bone levels around implants in the posterior mandible: 3-years results from a multicenter randomized clinical trial.

Evaluation of differences in the clinical performance and crestal bone levels between implants restored with single crowns with platform-matched or platform-switched abutments after 3 years.

Rocha S, Wagner W, Wiltfang J, Nicolau P, Moergel M, Messias A, Behrens E, Guerra F
J Clin Periodontol 2016;43:374-82


Long-term retrospective evaluation of the peri-implant bone level in onlay grafted patients with iliac bone from the anterior surperior iliac crest.

The purpose of the present study was to evaluate crestal bone level changes around dental implants after iliac bone augmentation in the long term.

Fretwurst T, Nack C, Al-Ghrairi M, Raguse JD, Stricker A, Schmelzeisen R, Nelson K, Nahles S
J Craniomaxillofac S 2015;43(6):956-60 (Grant CF41306)


A systematic review and meta-analysis of removable and fixed implant-supported prostheses in edentulous jaws: Post-loading implant loss.

The aim of this systematic review was to analyze post-loading implant loss for implant-supported prostheses in edentulous jaws, regarding a potential impact of implant location (maxilla vs. mandible), implant number per patient, type of prosthesis (removable vs. fixed), and type of attachment system (screw-retained, ball vs. bar vs. telescopic crown).

Kern JS, Kern T, Wolfart S, Heussen N
Clin Oral Implants Res 2016;27:174-95


Accuracy of three dimensional printed templates for guided implant placement based on matching a surface scan with CBCT.

To test whether digitally designed three-dimensional printed templates (D-temp) fabricated by matching surface scans and cone beam computed tomography (CBCT) images differ from the templates fabricated in-lab (L-temp) by using a physical transfer device for the positioning of the guiding sleeves.

Kernen F, Benic GI, Payer M, Schär A, Müller-Gerbl M, Filippi A, Kühl S
Clin Implant dent Relat Res 2016;18(4):762-8 (Grant CF20904)


Radiographic evaluation of conical tapered platform-switched implants in the posterior mandible: 1-year results of a two-center prospective study.

Long-term success of dental implants depends on healthy peri-implant soft tissues and adequate bone levels. This prospective study aims to assess bone level changes around implants with internal conical connection and platform-switching abutments in the posterior mandible.

Moergel M, Rocha S, Messias A, Nicolau P, Guerra F, Wagner W
Clin Oral Impl Res 2016;27:686-93


Impact of abutment microstructure and insertion depth on crestal bone changes at nonsubmerged titanium implants with platform switch.

To assess the impact of microgrooved abutments and the insertion depth on crestal bone changes at titanium implants with platform switch.

Schwarz F, Mihatovic I, Golubovic V, Schär A, Sager M, Becker J
Clin Oral Impl Res 2015;26:287-92 (Grant CF31101)


Influence of torque tightening on the position stability of the abutment in conical implant-abutment connection.

The influence of repeated system-specific torque tightening on the position stability of the abutment after de- and reassembly of the implant components was evaluated in six dental implant systems with a conical implant-abutment connection. An established experimental setup was used in this study.

Semper Hogg W, Zulauf K, Mehrhof J, Nelson K
Int J Prosthodont 2015;28:538-41 (Grant CF21101)


Impact of platform switching on marginal peri-implant bone-level changes. A systematic review and meta-analysis.

To address the focused question, is there an impact of platform switching (PS) on marginal bone level (MBL) changes around endosseous implants compared to implants with platform matching (PM) implant-abutment configurations?

Strietzel FP, Neumann K, Hertel M
Clin Oral Impl Res 2015;26:342-58


Accuracy of computer-aided template-guided oral implant placement: prospective clinical study.

The aim of the present study was to evaluate the in vivo accuracy of flapless, computer-aided implant placement by comparing the three-dimensional (3D) position of planned and placed implants through an analysis of linear and angular deviations.

Beretta M, Poli PP, Maiorana C
J Periodontal Implant Sci 2014;44:184-193


Platform switch versus platform match in the posterior mandible – 1-year results of a multicenter randomized clinical trial.

The purpose of this ongoing randomized study was to assess differences in bone level changes and success rates using implants supporting single crowns in the posterior mandible either with platform matched or platform switched abutments.

Guerra F, Wagner W, Wiltfang J, Rocha S, Moergel M, Behrens E, Nicolau P
J Clin Periodontol 2014;41:521-529


Immediately loaded distally cantilevered fixed mandibular prostheses supported by four implants placed in both in fresh extraction and healed sites: 2-year results from a prospective study.

To evaluate the outcome of immediately loaded distally cantilevered mandibular full-arch prostheses according to the ‘all-on-four’ concept supported by implants placed in both fresh extraction and healed sites.

Krennmair S, Seemann R, Weinländer M, Krennmair G, Piehslinger E
Eur J Oral Implantol 2014;7(2):173-84 (Grant CF41103)


Clinical efficacy of immediate implant loading protocols compared to conventional loading depending on the type of the restoration: A systematic review.

Immediate loading has become a predictable option to restore all clinical situations. The aim of this systematic review was to assess whether immediate loading protocols achieve comparable clinical outcomes when compared to conventional loading protocols depending on the type of prosthetic restoration.

Sanz-Sánchez I, Sanz-Martín I, Figuero E, Sanz M
Clin Oral Impl Res 2015;26(8):964-82


Immunohistochemical characteristics of regenerated bone after surgical therapy of advanced ligature-induced peri-implantitis defects.

This study seeks to assess and compare immunohistochemical characteristics of regenerated and pristine bone areas following surgical therapy of advanced peri-implantitis.

Schwarz F, Mihatovic I, Golubovic V, Becker J, Sager M
Clin Oral Invest 2014;18(6):1679-86 (Grant CF30801)


Minimierung der krestalen Knochenresorption. Einfluss von Implantat-Abutment-Verbindung und Positionierung der Implantatschulter.

Der Einfluss von Implantat-Abutment-Verbindung und Positionierung der Implantatschulter auf die krestale Knochenresorption nach einer Implantatinsertion.

Schwarz F
DFZ 2014;6:42-5


Impact of implant-abutment connection, positioning of the machined collar/microgap, and platform switching on crestal bone level changes. Camlog Foundation Consensus Report.

The aim of this consensus meeting was to assess the impact of implant–abutment connection, positioning of the machined collar/microgap, and platform switching on crestal bone level changes.

Schwarz F, Alcoforado G, Nelson K, Schaer A, Taylor T, Beuer F, Strietzel FP
Clin Oral Impl Res 2014;25:1301-03


Impact of implant-abutment connection and positioning of the machined collar/ microgap on crestal bone level changes: a systematic review.

To address the following focused question: What is the impact of implant–abutment configuration and the positioning of the machined collar/microgap on crestal bone level changes?

Schwarz F, Hegewald A, Becker J
Clin Oral Impl Res 2014;25:417-25


Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results.

The present study was first to evaluate the material-specific cellular tissue response of patients with head and neck cancer to a nanocrystalline hydroxyapatite bone substitute NanoBone (NB) in comparison with a deproteinized bovine bone matrix Bio-Oss (BO) after implantation into the sinus cavity.

Ghanaati S, Barbeck M, Lorenz J, Stuebinger S, Seitz O, Landes C, Kovács AF, Kirkpatrick CJ, Sader RA
Annals of Maxillofacial surgery 2013;3(2):126-38 (Grant CF 3.003)


Evaluation der Ästhetik durch unterschiedliche Fachdisziplinen mittels Pink Esthetic Score.

Ziel dieser Studie war die Langzeitevaluation von augmentativen Techniken in der ästhetischen Zone, die täglich in einer Privatpraxis angewandt werden. Untersucht wurden die Spezialisierung der Behandler und der daraus resultierende Einfluss auf die Beurteilung der Situation.

Hartmann A, Seiler M, Oeschey P, Dreyling M, Heinig N, Beuer F
Implantologie 2013;21(3):321-8 (Grant CF41202)


Influence of cement film thickness on the retention of implant-retained crowns.

The main goal of this study was to establish a new, high precision procedure to evaluate the influence of cement film thickness on the retention of cemented implant-retained crowns.

Mehl C, Harder S, Steiner M, Vollrath O, Kern M
J Prosthodont 2013;22(8):618-25


Die Implantat-Abutment-Verbindung.

Implantat-Abutment-Verbindungen zweiteiliger dentaler Implantate basieren auf zwei Prinzipien: Anschlagverbindungen werden von Konusverbindungen unterschieden. Die vorliegende Arbeit stellt eine Zusammenfassung der Charakteristiken beider Implantat-Abutment-Verbindungsprinzipien und der mit dem Verbindungstyp assoziierten mechanischen und klinischen Eigenschaften dar.

Nelson K, Zabler S, Wiest W, Schmelzeisen R, Semper-Hogg W
Implantologie 2013;21(4):355-63 (Grant CF21101)


An in vitro pilot study of abutment stability during loading in new and fatigue-loaded conical dental implants using synchrotron-based radiography.

The implant-abutment connection of a two-piece dental implant exhibits complex micromechanical behavior. A microgap is evident at the implant-abutment interface, even in the virgin state, and its width varies when an external mechanical load is applied.

Rack T, Zabler S, Rack A, Riesemeier H, Nelson K
Int J Oral Maxillofac Implants 2013;28:44-50 (Grant CF51002)


Effect of gabapentin-lactam and gamma-aminobutyric acid/lactam analogs on proliferation and phenotype of ovine mesenchymal stem cells.

Classic tissue engineering consists of three components: scaffold, cells, and growth or differentiation factors. Currently, expensive bone morphogenetic proteins are the most common substance used for hard tissue regeneration. An alternative could be gamma-aminobutyric acid/lactam (GABA-lactam) analogs.

Sauerbier S, Gutwald R, Wiedmann-Al-Ahmad M, Wolkewitz M, Haberstroh J, Obermeyer J, Kuenz A, Betz H, Wolter F, Duttenhöfer F, Schmelzeisen R, Nagursky H, Proksch S, Al-Ahmad A
Int J Oral Maxillofac Implants 2013;28:e230-e238 (Grant CF10701)


Impact of abutment material and dis-/re-connection on soft and hard tissue changes at implants with platform-switching.

To assess the impact of abutment material and dis-/re-connection on soft and hard tissue changes at implants with platform-switching.

Becker K, Mihatovic I, Golubovic V, Schwarz F
J Clin Periodontol 2012;39:774-780 (Grant CF30903)


Assessment of lipopolysaccharide microleakage at conical implant-abutment connections.

The aim of this in vitro study was to assess lipopolysaccharide microleakage at conical implant-abutment connections of two-piece dental implants in terms of the expression levels of genes involved in lipopolysaccharide-mediated proinflammatory cytokine production.

Harder S, Quabius ES, Ossenkop L, Kern M
Clin Oral Investig 2012;16:1377-1384 (Grant CF21004)


Patient preference and satisfaction with implant-supported mandibular overdentures retained with ball or locator attachments: a crossover clinical trial.

To determine patient satisfaction and preference for implant-supported mandibular overdentures (IOD) retained with ball or Locator attachments. In addition, peri-implant conditions and prosthodontic maintenance efforts for the final attachments were evaluated after 1 year of function.

Krennmair G, Seemann R, Fazekas A, Ewers R, Piehslinger E
Int J Oral Maxillofac Implants 2012;27:1560-1568 (Grant CF40802)


Analytical and experimental position stability of the abutment in different dental implant systems with a conical implant-abutment connection.

Position stability of the abutment should be investigated in four implant systems with a conical implant-abutment connection.

Semper-Hogg W, Kraft S, Stiller S, Mehrhof J, Nelson K
Clin Oral Investig 2013;17(3):1017-23 (Grant CF21102)


Accuracy of peri-implant bone thickness and validity of assessing bone augmentation material using cone beam computed tomography.

The aim of this study was to evaluate the accuracy of measuring bone thickness surrounding dental implants and the reliability of assessing existence and completion of osseous integration of augmentation material using a cone beam computed tomography (CBCT) system.

Wang D, Künzel A, Golubovic V, Mihatovic I, John G, Chen Z, Becker J, Schwarz F
Clin Oral Invest 2013;17(6):1601-9 (Grant CF51001)


Implant placement under existing removable dental prostheses and its effect on oral health-related quality of life.

One aim of this prospective clinical study was to measure the effects of strategicimplant placement under removable partial dental prostheses (RPDPs) and among removable complete dental prostheses (RCDPs) on oral health-related quality of life (OHRQoL).

Wolfart S, Moll D, Hilgers RD, Wolfart M, Kern M
Clin Oral Impl Res 2013;24(12):1354-9 (Grant CF2006)


Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial.

To assess whether differences occur in bone formation after maxillary sinus floor elevation surgery with bovine bone mineral (BioOss®) mixed with autogenous bone or autogenous stem cells. The primary endpoint was the percentage of new bone three months after the elevation procedure.

Rickert D, Sauerbier S, Nagursky H, Menne D, Vissink A, Raghoebar GM
Clin Oral Implants Res 2011;22:251-258 (Grant CF10701)


Effect of Gabapentin-Lactam and Gamma-Aminobutyric acid/lactam analogs on proliferation and phenotype of ovine mesenchymal stem cells.

Classic tissue engineering consists of three components: scaffold, cells, and growth or differentiation factors. Currently, expensive bone morphogenetic proteins are the most common substance used for hard tissue regeneration. An alternative could be gamma-aminobutyric acid/lactam (GABA-lactam) analogs.

Sauerbier S, Gutwald R, Wiedmann-Al-Ahmad M, Wolkewitz M, Haberstroh J, Obermeyer J, Kuenz A, Betz H, Wolter F, Duttenhöfer F, Schmelzeisen R, Nagursky H, Proksch S, Al-Ahmad A
Oral Craniofac Tissue Eng 2011:1:20-28 (Grant CF10701)


Bone marrow concentrate and bovine bone mineral for sinus floor augmentation: a controlled, randomized, single blinded clinical and histological trial – per-protocol analysis.

The purpose of this work was to evaluate the potential of substituting autogenous bone (AB) by bone marrow aspirate concentrate (BMAC). Both AB and BMAC were tested in combination with a bovine bone mineral (BBM) for their ability of new bone formation (NBF) in a multicentric, randomized, controlled, clinical and histological noninferiority trial.

Sauerbier S, Rickert D, Gutwald R, Nagursky H, Oshima T, Xavier SP, Christmann J, Kurz P, Menne D, Vissink A, Raghoebar G, Schmelzeisen R, Wagner W, Koch FP
Tissue Engineering: Part A 2011;17:2187-2197 (Grant CF10701)


Surgical therapy of advanced ligature-induced peri-implantitis defects: cone-beam computed tomographic and histologic analysis.

To evaluate radiological bone level (RBL) (i.e. cone-beam computed tomography) and histological bone levels (HBL) as well as re-osseointegration [bone-to-implant contact (BIC)] after surgical resective (i.e. implantoplasty) and/or regenerative therapy of advanced ligature-induced peri-implantitis in dogs.

Schwarz F, Sahm N, Mihatovic I, Golubovic V, Becker J
J Clin Periodontol 2011;38:939-949 (Grant CF30801)


Clinical outcome of root-shaped dental implants of various diameters: 5-year results.

The aim of this retrospective study was to evaluate the long-term survival and success rates of screw-type root-shaped (Camlog) implants of various diameters and their implant-prosthodontic reconstructions for more than 5 years of clinical use.

Krennmair G, Seemann R, Schmidinger S, Ewers R, Piehslinger E
Int J Oral Maxillofac Implants 2010;25:357-366 (Grant CF40801)


In vivo comparison of hard tissue regeneration with human mesenchymal stem cells processed with either the FICOLL method or the BMAC method.

In regenerative medicine open cell concentration systems are only allowed for clinical application under good manufacturing practice conditions. This study compares new bone formation in maxillary sinus augmentation procedures using biomaterial associated with mesenchymal stem cells (MSCs) separated by two different isolation methods.

Sauerbier S, Stricker A, Kuschnierz J, Bühler F, Oshima T, Xavier SP, Schmelzeisen R, Gutwald R
Tissue Eng Part C Methods 2010;16:215-223 (Grant CF10701)


Mesenchymal stem cells and bovine bone mineral in sinus lift procedures – an experimental study in sheep.

New reconstructive and less invasive methods have been searched to optimize bone formation and osseointegration of dental implants in maxillary sinus augmentation.

Sauerbier S, Stubbe K, Maglione M, Haberstroh J, Kuschnierz J, Oshima T, Xavier SP, Brunnberg L, Schmelzeisen R, Gutwald R
Tissue Eng Part C Methods 2010;16:1033-1039 (Grant CF10701)


Effects of repeated manual disassembly and reassembly on the positional stability of various implant-abutment complexes: an experimental study.

The purpose of this study was to evaluate rotational, vertical, and canting changes in the position of the rotation-safe component in the implant-abutment assemblies of five different implant systems (ITI, Steri-Oss, Camlog, Astra Tech, and Replace Select) after manual removal and reassembly.

Semper W, Heberer S, Mehrhof J, Schink T, Nelson K
Int J Oral Maxillofac Implants 2010;25:86-94 (Grant CF20901)


Comparison of Er:YAG laser, piezoelectric, and drill osteotomy for dental implant site preparation: A biomechanical and histological analysis in sheep.

The aim of this study was to examine the influence of implant bed preparation, using either Er:YAG laser ablation, piezoelectric surgery or drill osteotomy, on osseointegration of titanium dental implants after 4, 6, and 8 weeks.

Stübinger S, Biermeier K, Bächi B, Ferguson SJ, Sader R, von Rechenberg B
Lasers Surg Med 2010;42:652-661 (Grant CF30701)


Bone morphogenetic proteins 2, 5, and 6 in combination stimulate osteoblasts but not osteoclasts in vitro.

Bone regeneration is required for fracture healing. Various procedures have been used to promote osteogenesis with bone morphogenetic proteins (BMPs). We assessed the effects of BMP-2, BMP-5, and BMP-6 in isolated and combined use on the generation of osteoblasts and osteoclasts by comparing the osteoclastic potency of each on osteoclasts of primary murine bone marrow cells.

Wutzl A, Rauner M, Seemann R, Millesi W, Krepler P, Pietschmann P, Ewers R
J Ortho Res 2010;28:1431-1439 (Grant CF2006-2.004F)


Stability of crestal bone level at platform switched non-submerged titanium implants. A histomorphometrical study in dogs.

To investigate the influence of platform switching on crestal bone level changes at non-submerged titanium implants over a period of 6 months.

Becker J, Ferrari D, Mihatovic I, Sahm N, Schär A, Schwarz F
J Clin Periodontol 2009;36:532-539 (Grant CF30701)


Theoretical considerations: Implant positional index design.

Rotational freedom of implant positional indices in two-piece implants was investigated. The aim of the study was to determine, analytically, the rotational freedom of three different positional index designs, based on the hypothesis that it is not influenced by their geometric principle.

Semper W, Kraft S, Krüger T, Nelson K
J Dent Res 2009;88(8):725-730 (Grant CF50701)


Theoretical optimum of implant positional index design.

Rotational freedom of the implant-abutment connection influences its screw joint stability; for optimization, influential factors need to be evaluated based on a previously developed closed formula. The underlying hypothesis is that the manufacturing tolerances, geometric pattern, and dimensions of the index do not influence positional stability.

Semper W, Kraft S, Krüger T, Nelson K
J Dent Res 2009;88(8):731-735 (Grant CF50701)


Maxillary sinus grafting with a nano-structured biomaterial: Preliminary clinical and histological results.

In this study the potential of a new and entirely synthetic, nano-structured hydroxyapatite-based biomaterial for sinus floor augmentation is evaluated.

Stübinger S, Ghanaati S, Orth C, Hilbing U, Saldamli B, Biesterfeld S, Kirkpatrick CJ, Sader RA
Eur Surg Res 2009;42:143-149 (Grant CF2006-3.003F)


Application of a new chair-side method for the harvest of mesenchymal stem cells in a patient with nonunion of fracture of the atrophic mandible – a case report.

This case report describes a new clinical method for chair-side processing of a cell mixture which contains mesenchymal stem cells (MSCs) which was applied for the first time in the treatment of a nonunion of an atrophic fractured mandible.

Wongchuensoontorn C, Liebehenschel N, Schwarz U, Schmelzeisen R, Gutwald R, Ellis E 3rd, Sauerbier S
J Craniomaxillofac Surg. 2009;37:155-161 (Grant CF10701)


Crestal bone changes at nonsubmerged implants (Camlog) with different machined collar lengths: a histomorphometric pilot study in dogs.

The aim of the present study was to histomorphometrically investigate crestal bone changes at nonsubmerged implants (Camlog) with different machined collar lengths in a dog model.

Schwarz F, Herten M, Bieling K, Becker J
Int J Oral Maxillofac Implants 2008;23:335-342 (Grant CF30702)


Influence of platform switching on crestal bone changes at non-submerged titanium implants: a histomorphometrical study in dogs.

The aim of the present study was to investigate histomorphometrically the influence of platform switching on crestal bone changes at non-submerged wide-body titanium implants in a dog model.

Becker J, Ferrari D, Herten M, Kirsch A, Schär A, Schwarz F.
J Clin Periodontol 2007;34:1089-1096 (Grant CF30702)


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